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Publications

2008   2007   2006   2005   2004   2003   2001   2000  1999  1998  1996  1995  1994

(2008)

Jamburuthugoda, V.K., Santos-Velazquez, J.M., Skasko, M., Operario, D.J., Purohit, V., Chugh, P., Szymanski, E.A., Wedekind, J.E., Bambara, R.A., and Kim, B. (2008) Reduced dNTP Binding Affinity of 3TC-resistant M184I HIV-1 Reverse Transcriptase Variants Responsible for Viral Infection Failure to Macrophages and in vivo Instability. J. Biol. Chem. Jan 24; [Epub ahead of print].

MacElrevey, C. & Wedekind, J.E. (2008) “Chapter 16: Chemistry, Phylogeny and Structure of the APOBEC Family". in RNA and DNA Editing:Molecular Mechanisms and their Integration into Biological Systems. H.C. Smith (Ed), Wiley-Interscience, New Jersey, 369-340.

Bennett, R.P., Presnyak, V., Wedekind, J.E. and Smith, H.C. (2007) Nuclear exclusion of the HIV-1 host defense factor APOBEC3G requires a novel cytoplasmic retention signal and is not dependent on RNA binding. J Biol Chem. Dec 28; [Epub ahead of print].

Spitale, R.C., Heller, M.G., Pelly, A.J. & Wedekind, J.E. (2007) The efficient syntheses of 5´-deoxy-5´-fluoro-guanosine and –inosine. J. Org. Chem. 72, 8551-4.

MacElrevey C, Spitale R.C., Krucinska J. & Wedekind, J.E. (2007) A posteriori design of crystal contacts to improve the X-ray diffraction properties of a small RNA enzyme. Acta Crystallogr. D Biol. Crystallogr. 63, 812-25.

Torelli A.T., Krucinska J. & Wedekind J.E. (2007) A comparison of vanadate to a 2'-5' linkage at the active site of a small ribozyme suggests a role for water in transition-state stabilization. RNA 13, 1052-70.

Lehmann D.M., Galloway C.A., MacElrevey C., Sowden M.P., Wedekind J.E. & Smith H.C. (2007) Functional characterization of APOBEC-1 complementation factor phosphorylation sites. Biochim Biophys Acta 1773, 408-18.

Wedekind*, J.E., Gillilan, R., Krucinska, J., Janda, A., Salter, J.D., Raina, J. & Smith*, H.C. (2006) Nano-structures of APOBEC3G support a hierarchical assembly model of high molecular mass ribonucleoprotein particles from dimeric subunits. J. Biol. Chem. 281, 38122-381126.

Salter, J., Krucinska, J., Alam, S., Grum-Tokars, V. and Wedekind, J.E. (2006) Water in the active site of an all-RNA hairpin ribozyme and the effects of G8 base variants on phosphoryl transfer geometry. Biochemistry 45, 686-700.

Bennett R.P., Diner E., Sowden M.P., Lees J.A., Wedekind J.E. & Smith HC. (2006) APOBEC-1 and AID are nucleo-cytoplasmic trafficking proteins but APOBEC3G cannot traffic. Biochem. Biophys. Res. Commun. 350, 214-219.

Ghosh, A.K., Sridhar, P.R., Hussain^, A.K., Leshchenko, S., Li, J., Walters, D.E., Wedekind, J.E., Tokars, V.L. Maeda K., Gatanaga, H., and Hiroaki Mitsuya. (2006) Structure-Based Design of HIV-1 Protease Inhibitors to Combat Drug Resistance. J. Med. Chem. 49, 5252-5261.

Ichikawa, H.T., Sowden, M.P., Torelli, A.T., Bachl, J., Huang, P., Dance G.S.C., Marr, S.H., Robert, J., Wedekind, J.E., Smith, H.C., Bottaro, A. (2006) Structure and Phylogenetic Analysis of Activation Induced Deaminase function. J. Immunol. 176, 355-361.

Chaves, F., Richards, K., Torelli, A.T., Wedekind, J. and Sant, A.J. (2006) Two peptide-binding motifs for the I-A^d MHC class II molecule: Alternative pH-dependent binding behavior and implications for immunodominance in immune responses. Biochemistry 45, 6426-6433.

Alam, S., Grum-Tokars, V., Krucinska, J., Kundracik, M.L. and Wedekind, J.E. (2005) Conformational heterogeneity at position U37 of an all-RNA hairpin ribozyme with implications for metal binding and the catalytic structure of the S-turn. Biochemistry 44, 14396-14408.

Smith,* H.C., Wedekind,* J.E., Xie K. and Sowden M.P. (2005)  "Mammalian C to U Editing. Topics in Current Genetics": in Fine-Tuning of RNA Functions by Modification and Editing H. Grosjean (Ed.) Springer-Verlag, Berlin, 1610-2096.

MacElrevey, C. & Wedekind, J.E. (2005) Crystallization and X-ray Diffraction Analysis of the Trp/Amber Editing Site of Hepatitis Delta Virus (+)RNA – A case of rational design. Acta Cryst. F, 1049-1053.

Gruswitz, F., Frishman, M., Goldstein, B. M. and Wedekind, J. E. (2005) Coupling of MBP Fusion Protein Cleavage with Sparse Matrix Crystallization Screens to Overcome Problematic Protein Solubility BioTechniques 39, 476-480.

Xie, K., Song, S.-C., Spitalnik, S.L. and Wedekind, J.E. (2005) Crystallographic analysis of the NNA7 Fab and proposal for the mode of human blood-group antigen recognition. Acta Cryst. D61, 1386-1394.

Jamburuthugoda, V.K., Gua, D.D., Wedekind, J.E. and Kim, B. (2005) Kinetic Evidence for Interaction of Human Immunodeficiency Virus Type 1 Reverse Transcriptase with the 3’-OH of the Incoming dNTP Substrate. Biochemistry 44, 10635-10643.

Smith, H.C., Bottaro, A. Sowden, M.P. & Wedekind, J.E. (2004) Activation Induced Deaminase: the Importance of Being Specific. Trends in Genetics 20, 224-227.

Goodman, J., Wang, S., Alam, S., Ruzicka, F.J., Frey P.A. and Wedekind, J.E. (2004) Ornithine Cyclodeaminase: Structure, Mechanism of Action and Implication for the mu-Crystallin Family. Biochemistry 43, 13883-13891.

Xie, K., Sowden, M.P., Dance, G.S.C., Torelli, A.T., Smith, H.C. & Wedekind, J.E. (2004) The Structure of a Yeast RNA Editing Deaminase Provides Insight into the Fold and Function of Activation-Induced Deaminase and APOBEC-1. Proc. Natl. Acad. Sci. U.S.A. 101, 8114-8119

Alam, S., Wang, S., Ruzicka, F.J., Frey, P.A. & Wedekind, J.E. (2004) Crystallization and X-ray Diffraction Analysis of Ornithine Cyclodeaminase from Pseudomonas putida. Acta Cryst D60, 941-944.

Song, S.C., Xie, K., Czerwinski, M., Spitalnik, S.L. & Wedekind, J.E. (2004) Purification, Crystallization and X-ray Diffraction Analysis of a Recombinant Fab that Recognizes a Human Blood Group antigen. Acta Cryst. D60, 788-791.

Wedekind, J.E., Dance, G.S.C., Sowden, M.P., & Smith, H.C. (2003) Messenger RNA Editing in Mammals: New Members of the APOBEC Family Seeking Roles in the Family Business. Trends in Genetics 19, 207-216.

Wedekind, J.E. & McKay, D.B. (2003) Crystal Structure of the Leadzyme at 1.8 Å resolution: Metal Ion Binding and the Implications for Catalytic Mechanism and Allo Site Ion regulation. Biochemistry 42, 9554-9563.

Grum-Tokars, V., Milovanovic, M. & Wedekind, J.E. (2003) Crystallization and X-ray diffraction analysis of an all-RNA U39C mutant of the minimal hairpin ribozyme. Acta Cryst. D59, 142-145.

Wedekind, J.E., Trame, C.B., Dorywalska, M., Koehl, P., Raschke, T.M., McKee, M., FitzGerald, D., Collier, R.J., and McKay, D.B. (2001) Refined Crystallographic Structure of Pseudomonas aeruginosa Exotoxin A and its Implications for the Molecular Mechanism of Toxicity. J. Mol. Biol. 314, 823-837.

(2000)

Wedekind, J.E. & McKay, D.B. (2000) Purification, Crystallization, and X-ray Diffraction Analysis of Small Ribozymes.  Meth. Enzymol. 317, 149-168.

Wedekind, J.E. & McKay, D.B. (1999) Crystal Structure of a Lead-Dependent Ribozyme Revealing Metal Binding Sites Relevant to Catalysis. Nature Structural Biology 6, 261-268.

 McKay, D.B. & Wedekind, J.E. (1999) Small Ribozymes, in The RNA World, Second Edition (Tom Cech, Ed.), Cold Spring Harbor Press, 265-286.

Wedekind, J.E. & McKay, D.B. (1998) Crystallographic Structures of the Hammerhead Ribozyme: Relationship to Ribozyme Folding and Catalysis. Ann. Rev. Biophys. and Biomolec. Struct. 27, 475-502.

Reed, G.H., Poyner, R.R., Larsen, T.M., Wedekind, J.E, & Rayment, I. (1996) Structural and Mechanistic Studies of Enolase. Curr. Opin. Struct. Biol. 6, 736-743.

Babbitt, P.C., Hasson, M.S., Wedekind, J.E., Palmer, D.R., Reed, G.H., Rayment, I., Ringe, D., Kenyon, G.L., & Gerlt, J.A. (1996) The Enolase Superfamily: A General Strategy or Enzyme-catalyzed Abstraction of the alpha-Protons of Carboxylic Acids. Biochemistry 35, 16489-1650.

Wedekind, J.E., Frey, P.A., & Rayment, I. (1996) The Structure of Nucleotidylated His-166 of Galactose-1-Phosphate Uridylyltransferase Provides Insight Into Phosphoryl Group Transfer.  Biochemistry 35, 11560-11569.

Larsen, T.M., Wedekind, J.E., Rayment, I. & Reed, G.H. (1996)  A Carboxylate Oxygen of the Substrate Bridges the Magnesium Ions at the Active Site of Enolase: Structure of the Yeast Enzyme Complexed with the Equilibrium Mixture of 2-Phosphoglycerate and Phosphoenolpyruvate at 1.8 Å Resolution.  Biochemistry, 35, 4349-4358.

Wedekind, J.E., Frey, P.A. & Rayment, I. (1995) Three-Dimensional Structure of Galactose-1-phosphate Uridylyltransferase from Escherichia coli at 1.8 Å Resolution. Biochemistry 34, 11049-11061.

Ruzicka, F.J., Wedekind, J.E., Kim, J., Rayment, I. & Frey, P.A. (1995)  Galactose-1-Phosphate Uridylyltransferase from Escherichia coli is a Zinc and Iron Metallo-enzyme.  Biochemistry 34, 5610-5617.

Wedekind, J.E., Reed, G.H. & Rayment, I. (1995)  Octahedral Coordination at the High Affinity Metal Site in Enolase: Crystallographic Analysis of the Mg(II)-Enzyme from Yeast at 1.9 Å Resolution.  Biochemistry 34, 4325-4330.

Wedekind, J.E., Poyner, R.R., Reed, G.H. & Rayment, I. (1994)  Chelation of Serine 39 to Mg²⁺ Latches a Gate at the Active Site of Enolase: Structure of the Bis(Mg²⁺) Complex of Yeast Enolase and the Intermediate Analog Phosphonoaceto-hydroxamate at 2.1 Å Resolution.  Biochemistry 33, 9333-9342.

Wedekind, J.E., Frey, P.A. & Rayment, I. (1994) Crystallization and Preliminary Crystallographic Analysis of Galactose-1-Phosphate Uridylyltransferase from Escherichia coli. Acta Cryst. D 50, 329-331.

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