Wedekind, J.E. (2009) “A Structural and Functional Characterization of APOBEC3G in Multiple Oligomeric States”, The 2009 Gordon Research Conference on RNA and DNA Editing and Modification, Galveston Island, Texas, January 11^th to 16^th.

Wedekind, J.E. (2008) “Use of SAXS to Interrogate a Known Crystal Structure as a Basis for Modeling the HIV Defense Factor APOBEC3G”, (Abstract W0069) The American Crystallographic Association Annual Meeting, Knoxville, TN.

Wedekind, J.E. (2008) “ How Base Substitutions Alter the Core Fold of a Non-Coding RNA, & Ab Initio Shape Restoration of APOBEC3G, an anti-HIV DNA Deaminase”. Dept. of Molecular & Cell Biology, The University of Texas at Dallas (Tianbing Xia – host), May. 8^th.

Wedekind, J.E. (2008) “Nucleobase Substitutions, Deletions and Modifications in the Core of a Small Ribozyme: A Demonstration of Structural Resilience with Some New Twists”. Dept. of Chemistry, The Pennsylvania State University (Phil Bevilacqua – host), April. 22^nd.

Wedekind, J.E. (2008) “Progress on the structural characterization of APOBEC3G, an endogenous anti-HIV factor”, OSU Biochemistry Program, The Ohio State University. (Juan Alfonso – Host), Jan. 15^th.

Wedekind, J.E. (2007) “Combining Small Angle X-ray Scattering in Solution with Single Crystal X-ray Diffraction in the Analysis of Core Abasic Modifications of a Small RNA Enzyme.” The Pittsburgh Diffraction Conference, Buffalo NY, Oct. 25^th-27^th.

Wedekind, J.E. (2007) “Structure and function analysis of the anti-retroviral DNA cytidine deaminase APOBEC3G”, FEBS Conference on DNA and RNA modification Enzymes: Comparative Structure, Mechanism, Function and Evolution, Aussois France, Sept. 11-16^th.

Wedekind, J.E. (2007) “Cavity or Collapse? Structural consequences of abasic substitutions within the core of a small RNA enzyme” (Abstract 153), The 234^th Meeting of the American Chemical Society, Boston MA, August 19^th to 23^rd.

Wedekind, J.E. (2007) “Small Angle X-ray Scattering Provides Insight into the Mode of RNA-Mediated Regulation of APOBEC3G Anti-HIV Activity”, The Cornell High Energy Synchrotron Source Annual Users’ Meeting, Ithaca NY, June 12-13th

Wedekind, J.E. (2007) “Nanostructures of APOBEC3G Support a Hierarchical Assembly Model of High Molecular Mass Ribonucleoprotein Particles from Dimeric Subunits", The National Cancer Institute, Frederick, MD (Dr. Vinay Pathak – Host), February 21^st.

Wedekind, J.E. (2007) “Nanostructures of APOBEC3G Support a Hierarchical Assembly Model of High Molecular Mass Ribonucleoprotein Particles from Dimeric Subunits", The 2007 Gordon Research Conference on RNA Editing, Ventura CA, January 14-19.

Wedekind, J.E. (2006) “Global Folding with Local Restructuring Accompanies Abasic Nucleotide Substitutions in the Core of a Small Catalytic RNA", Faculty Lectures Series, The Rochester Institute of Technology, Dept of Chemistry (Dr. Suzanne O’Handley – Host), Rochester, NY, Dec 5^th.

Wedekind, J.E. (2006) “Global Folding with Local Restructuring Accompanies Abasic Nucleotide Substitutions in the Core of a Small Catalytic RNA", The 2006 Harrison Howe Award Symposium, Rochester Division of the American Chemical Society, Rochester, NY, Oct 16^th.

Wedekind, J.E. (2005) “'You win some, you lose some': insights into the hairpin ribozyme mechanism through structural analysis of suppressor and loss-of-function mutants"”, Dept. Microbiology & Molecular Genetics, University of Vermont, Feb 9^th (host – John Burke).

Wedekind, J.E. (2004) “The crystal structure of an RNA editing deaminase from yeast provides insight into the fold and function of AID and APOBEC-1 -- Crystal structure of the U39C mutant of the Hairpin Ribozyme”. Dept. of Biochemistry & Molecular Biology, SUNY Upstate Medical University, Syracuse NY, 5 April. (host – Stewart Loh)

Wedekind, J.E. (2003) “The structure of the yeast cytidine deaminase provides insight into the fold and function of RNA editing enzyme APOBEC-1”, 12^th Annual Buffalo-Hamilton-Toronto Crystallographic Symposium, McMaster University, Hamilton Ontario, Canada, Nov. 21^st.

Wedekind, J.E. (2003) “The crystal structure of CDD1 from yeast provides insight into the fold and function of APOBEC-1, a mammalian C to U mRNA editase. Hauptman-Woodward Medical Research Institute, Buffalo, NY, 24 February (host – George DeTita).

Wedekind, J.E. (2003) “Developing a model editase: using structure to predict the molecular function of APOBEC-1-related proteins”, Bioinformatics and Structural Biology, The Gordon Research Conference on RNA Editing, Ventura CA, Jan. 19-24^th.

Wedekind, J.E. (2002) “The structure of CDD1 suggests a new model for APOBEC-1 that includes a flexible linker at the active site”. Session X: RNA in Disease and RNA Editing, The Seventh Annual Meeting of the RNA Society, Madison WI, June 2^nd.

Wedekind, J.E. (2002) “The Structure of Yeast Cytidine Deaminase CDD1-an Orphan C to U RNA Editase at 2.2 Å Resolution.” Kimmel Cancer Center, Thomas Jefferson University, PA (host - Charlie Brenner).

Wedekind, J.E. (2002) “The Structure of Yeast Cytidine Deaminase CDD1-an Orphan C to U RNA Editase at 2.2 Å Resolution.” Dept. Biochemistry & Molecular Biology, Michigan State University (host - William Smith).

Wedekind, J.E. (2002) “The Structure of Yeast Cytidine Deaminase CDD1-an Orphan C to U RNA Editase at 2.2 Å Resolution.” Dept. of Biochemistry, North Carolina State University (host - Dennis Brown).

Wedekind, J.E. (2002) “The Structure of Yeast Cytidine Deaminase CDD1-an Orphan C to U RNA Editase at 2.2 Å Resolution.” Dept. of Chemistry, Pennsylvania State University (host – Phil Bevilacqua).

Wedekind, J.E. (2002) “The Structure of Yeast Cytidine Deaminase CDD1-an Orphan C to U RNA Editase at 2.2 Å Resolution.” Dept. of Biochemistry, Wake Forest University School of Medicine (host - Leslie Poole).

Wedekind, J.E. (2001) “The Structure of Yeast Cytidine Deaminase CDD1-an Orphan C to U RNA Editase at 2.2 Å Resolution.” Program in Genetics, University of Mass. Med. School (host - Michael Green).

Wedekind, J.E. (2001) “The Structure of Yeast Cytidine Deaminase CDD1-an Orphan C to U RNA Editase at 2.2 Å Resolution.” Dept of Chemistry & Biochemistry, University of Texas at Austin (host - Jon Robertus).

Wedekind, J.E. (2001) “The Structure of Yeast Cytidine Deaminase CDD1-an Orphan C to U RNA Editase at 2.2 Å Resolution.” Department of Biochemistry Seminar, Vanderbilt University School of Medicine, (host - Michael Waterman).

Wedekind, J.E. (2000) “Crystal Structure of a Lead-Dependent Ribozyme Revealing Metal Binding Sites Relevant to Catalysis”. Dept of Biochemistry Seminar, U.W. Madison (host - Perry Frey).

Wedekind, J.E. (1999) “Structural Studies of Small Ribozymes and a survey of crystallography at Chicago Medical School”. Dept. of Physiology & Biophysics Seminar (host - Celia Sladek).

Wedekind, J.E. (1999) “Crystal Structure of a Lead-Dependent Ribozyme Revealing Metal Binding Sites Relevant to Catalysis”. Dept of Biochemistry Seminar, Purdue University (host - Barbara Golden).

Lectures Sponsored by the University of Rochester

Wedekind, J.E. (2005) “Mutation U39C causes a structural rearrangement in the S-turn of the Hairpin Ribozyme”, Dept. of Chemistry, University of Rochester, April 18^th (host – Doug Turner).

Wedekind, J.E. (2005) “RNA Enzymes”. Novel Targets Session, The Annual James Wilmot Cancer Center Symposium, Memorial Art Gallery, Rochester NY, Oct. 9^th.

Wedekind, J.E. (2004) “Structural and Mechanistic Studies of the Hairpin Ribozyme by use of single atom mutagenesis”, BMCB 3^rd Annual Cluster Retreat, University of Rochester Steamboat Landing, NY.

Wedekind, J.E. (2003) “Structural studies of RNA editing enzymes provide insight into the fold and function of DNA mutases implicated in cancer”. Novel Targets Session, The Annual James Wilmot Cancer Center Symposium, Memorial Art Gallery, Rochester NY, 9 Oct.

Wedekind, J.E. (2002) “Crystal Structure of a Junctionless hairpin ribozyme 64-mer; architecture of the minimal all RNA motif at 3.35 Å resolution”, BMCB 1^st Annual Cluster Retreat, Rochester Museum and Science Center and Strasenburgh Planetarium, NY.

Wedekind, J.E. (2002) “The Structure of Yeast Cytidine Deaminase CDD1-an Orphan C to U RNA Editase at 2.2 Å Resolution.” Dept. Biochemistry & Biophysics, University of Rochester.

Published Abstracts and Presentations at National Meetings (Lab Members & Collaborators)

Salter J., Krucinska J., Bennett R., Galloway C., Gillilan R., Smith H. & Wedekind, J. (2008) “Reconstruction of Molecular Envelopes by SAXS has Implications for Molecular Modeling of APOBEC3G and the APOBEC-1 Complementation Factor (ACF)” (Poster W0352). The American Crystallographic Association Annual Meeting, Knoxville, TN.

Spitale, R. & Wedekind, J.E. (2008) Trapping a Pre-Ligation Hairpin Ribozyme Complex by Use of 5'-Deoxy- 5'-Fluoro- Guanosine (Poster W0078). The American Crystallographic Association Annual Meeting, Knoxville, TN.

Torelli, A.T. & Wedekind, J.E. (2005) “Mutants of HIGM2 in relation to AID structure and function”, Biological Roles of the APOBEC Proteins, The Gordon Research Conference on RNA Editing and Processing, Ventura CA, Jan. 23-28^th. (oral presentation)

Alam S. & Wedekind, J.E. (2004) “Structural and Mechanistic Studies of the Hairpin Ribozyme by use of Single Atom Mutagenesis”, 13^th Annual Buffalo-Hamilton-Toronto Symposium, McMaster University, Hamilton ON, 5 Nov. (oral presentation)

Goodman J.L. & Wedekind, J.E. (2004) “Ornithine Cyclodeaminase: Structure, Mechanism of Action and Implication for the m-Crystallin Family”, 13^th Annual Buffalo-Hamilton-Toronto Symposium, McMaster University, Hamilton ON, 5 Nov. (oral presentation)

Xie, K., Sowden, M.P., Dance, G.S.C., Torelli, A.T., Smith, H.C. and Wedekind, J.E. (2004) The crystal structure of an RNA editing deaminase from yeast provides insight into fold and function of AID and APOBEC-1. Poster 268, The Ninth Annual Meeting of the RNA Society, Madison WI, June 1^st – June 6^th.

MacElrevey, C. & Wedekind, J.E. (2004) Crystallographic Analysis of the Trp/Amber Editing Site of the Hepatitis-d-virus: Discerning the rules of ADAR engagement. Poster 259, The Ninth Annual Meeting of the RNA Society, Madison WI, June 1st – June 6th.

Wedekind, J.E. & Grum-Tokars, V. (2004) The U39C mutation of the Hairpin Ribozyme creates a domain rearrangement in the S-turn. Poster 443, The Ninth Annual Meeting of the RNA Society, Madison WI, June 1^st – June 6^th.

Spitalnik S., Song, S., Xie, K. and Wedekind J.E (2004) Crystal structure of NNA7, an Fab fragment that recognizes the glycopeptide N blood group antigen, AABB Meeting, Baltimore MD, October 26^th (04-AB-709-AABB). (oral presentation)

Song S.-C., Xie, K., Spitalnik, S.L., and Wedekind, J.E. (2004) Crystal Structure of NNA7 at 1.75 Å resolution; an Fab Fragment that Recognizes a Human Blood-Group Glycopeptide Antigen on Glycophorin A. Keystone Symposium on Protein Structure, April 13^th-19^th, Keystone, CO. (oral presentation)

Wang M.N., Grum-Tokars, V, Wedekind, J.E., Kemp R.G. (2004) Crystallization and structure analysis of Borrelia burgdorferi pyrophosphate-dependent phosphofructokinase in complex with its product fructose 1,6-bisphosphate. The Biophysical Society Meeting, in Biophysical Journal S86, 490A-491A. (poster)

Wedekind, J.E., Sowden, M., Xie, K., Dance, G., Smith, H.C. (2002) The structure of Cdd1 suggests a new model for APOBEC-1 that includes a flexible linker at the active site. Poster 517, The Seventh Annual Meeting of the RNA Society, Madison WI, May 28^th – June 2^nd.

Wedekind, J.E., Xie, K., Walters, D.E., Sowden, M., Dance, G., Smith, H.C. (2002) The structure of yeast Cdd1 provides insight into the  molecular determinants of apoB mRNA editing. Poster 518, The Seventh Annual Meeting of the RNA Society, Madison WI, May  28^th – June 2^nd.