Bill Simon

William Simon Ph. D. Harvard University,.

Professor of Biochemistry and Biophysics at the University of Rochester.

Not the William Simon who was formally Secretary of the Treasury nor the William Simon for whom the famous Business School at the University of Rochester is named.Nor am I Senator Simon or the singer Simon. I am however a full Professor at the University of Rochester School of Medicine where I have served as a technical consultant to the Medical center and have taught Physics and Mathematics.

Prior to joining the faculty at Rochester I served as a technical consultant at the Harvard Medical School for four years.

In the course of my work I have published about 70 papers and a textbook of Mathematical Techniques in Biology and Medicine (Dover) now in its third edition.

My publications have covered a wide variety of fields as dictated by the demands of various consultations but are mostly in the fields of computer applications particularly to image processing and image presentation.

SELECTED ARTICLES BY WILLIAM SIMON

1. Simon, W. SNAP: An interpretive real-time computer language for biology. Medical and Biological Engineering 6: 83, 1968.

2. Wright, B., Simon, W. and Walsh, B.T. A kinetic model of metabolism essential to differentiation in dictyostelium discoideum. Proceedings of the National Academy of Sciences 60: 644, 1968.

3. Tretiak, O.J., Eden, M. and Simon, W. Pattern recognition and image processing: Internal structure from X-ray images. International Conference on Engineering in Medicine and Biology, Chicago, 1969.

4. Simon, W. A method of exponential separation applicable to small computers. Physics in Medicine and Biology 15: 355, 1970.

5. Simon, W. A scheme for accelerated floating point operation in small computers. Computers and Biomedical Research 3: 238, 1970.

6. Simon, W. "Back-to-the-wall" effect? Science, Nov. 1971, Jan 1974; Wall Street Journal, October 15, 1974.

7. Garvey, C.F., Young, J.H., Coleman, P.D. and Simon, W. Automated three-dimensional dendrite tracking system. Journal of Electro-Encephalography and Clinical Neurophysiology 35: 199, 1973.

8. Simon, W. Advanced techniques for the small computer, Chapter 11 of Digital Computers in the Behavioral Laboratory, ed. by B. Weiss, pp. 427-456, Appleton-Century-Crofts, 1973.

9. Kay, D.B., Keyes, J.W., Jr. and Simon, W. Radionuclide tomographic image reconstruction using Fourier transform techniques. Journal of Nuclear Medicine 15: 981, 1974.

10. Walters, T.E., Simon, W., Chesler, D.S. and Correia, J.A. Radionuclide axial tomography corrected for internal gamma ray absorption. Information Processing in Scinitigraphy: Proceedings of the IVth International Conference, Orsay, France, July 1975, p. 333.

11. Simon, W. A three-dimensional computer display. Computer Graphics and Image Processing 4: 396, 1975.

12 .Simon, W. and Eden, M. Three-dimensional measurements from scanning electron micrographs by electron scribing. Review of Scientific Instruments 47: 443, 1976.

13. Isenberg, J. and Simon, W. Radionuclide axial tomography by half back-projection. Physics in Medicine and Biology 23: 154, 1978.

14. Eden, M. and Simon, W. Direct measurement of red blood cell profiles. Three-Dimensional Imaging: Proceedings of SPIE's Twenty-first International Technical Symposium and Instrument Display, San Diego, CA, August 1977, Vol. 120, p. 195.

15. Segel, G., Simon, W. and Lichtman, M. A model for the control of potassium transport in PHA-stimulated human blood lymphocytes. Presented at 12th International Leukocyte Culture Conference. Soroka Medical Center, Beersheba, Israel, June 25-30, 1978.

16. Segel, G., Simon, W. and Lichtman, M. The regulation of sodium and potassium transport in phytothemagglutinin-stimulated human blood lymphocytes. Journal of Clinical Investigation 64: 834, 1979.

17. Simon, W. Methods for improved resolution and absorption correction in emission tomography. Seminar presented at Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland, June 1979.

18. Simon, W. and Blumenthal, S. A high resolution interactive image scanner. IEEE Transactions on Biomedical Engineering 27: 468, 1980.

19. Simon, W. Avoiding megamouse experiments. Journal of Toxicology and Environmental Health 6: 101, 1980.

20. Walters, T.E., Simon, W., Chesler, D.S. and Correia, J.A. Attenuation correction in gamma emission tomography. Journal of Computer Assisted Tomography 5: 89-94, 1981

21. Segel, G.B., Lichtman, M.A. and Simon, W. Variables that affect timing of bone marrow transplantation in patients with chronic myelogenous leukemia (CML). Presented at the 27th Annual Meeting of The American Society of Hematology. Blood 68(5): 1055-1064, 1986.

22. Simon, W. Public School Teaching: An Alternative. Science, p. 267, Jan 16, 1987.

23. Simon, W., Segel, G.B. and Lichtman, M.A. Upper and lower time limits in the decision to recommend marrow transplanation for patients with chronic myelogenous leukemia. Brit. J. Hematol. 70: 31-36, 1988.

24 Simon, W., Segel, G.B. and Lichtman, M.A. Upper and lower time limits in the decision to recommend marrow transplanation for patients with chronic myelogenous leukemia. Brit. J. Hematol. 70: 31-36, 1988.

25. Maillie, H.D., Baker, J.V., Simon, W., Watts, R.J. and Quinn, B.R. Age related rejoining of broken chromosomes in human leukocytes following x-irradiation. Mechanisms of Ageing and Dev., 65:229-238, 1992.

26. Maillie, H.D., Simon, W. and Watts, R.J. and Quinn, B.R. Determining person-years of life lost using the BEIR V method. Health Physics, 64:461-466, 1993.

27. Spar, I., Simon, W. and Pryor, K.C. The effect of debt level on the residency preferences of graduating medical students. Academic Medicine, 68(7):570-572, 1993.

28. Maillie, D.H., Simon, W., Greenspan, B.S., Watts, R.J. and Quinn, B.R. The influence of life table corrections for smokers and nonsmokers on the health effects of radon using the BEIR IV method. Health Physics, 66(6):615-620 (1994).

29. Maillie, D.H., Simon, W. A method of estimating the loss of life expectancy from lifetime exposure to low dose rate radiation. Journal of the Franklin Institute, Vol. 332A, pp. 93-100,1995.

30. Simon,W. A Simple Stereoscopic Endoscope. Journal of the Society of Laparoendoscopic Surgeons. Jan-March 1998.

31. Morsch, BS, William Simon, PhD, and Paul D. Coleman, PhD. Neurons May Live for Decades with Neurofibrillary TanglesAuthors: Renee Morsch, BS, William Simon, PhD, and Paul D. Coleman, PhD Journal: Journal of Neuropathology and Experimental Neurology, Vol. 58, No.2, February 1999, pp. 188-197

32. Weiss,B.,Clarkson, T,W. Simon W. Silent Latency Periods in Methylmercury Poisoning and in Neurodegenerative Disease. Environmental Health Vol. 110, October 2002, pp 851-854

33.Custer, A.W.,Kazarinova-Noyes, K., Sakurai,T.,Xu, X.,Simon, W.,Grumet.M.,Shrager,P. The role of ankyrin-binding protein NrCAM in node of Ranviier formation. Journal of Neuroscience. 5 November 2003; Vol. 23, No. 31

34. Shrager P, Simon W, Kazarinova-Noyes K (2005) Na+ Channel Reorganization in Demyelinated Axons. In Multiple Sclerosis as a Neuronal Disease. Edited by Stephen G. Waxman . Elsevier Academic Press 2005.

BOOKS

Simon, W. Mathematical Techniques for Biology and Medicine, Dover, New York,

NY, 1986, 3rd Edition. Originally published as Mathematical Techniques for Physiology and Medicine, Academic Press, New York, 1972. 2nd Edition, MIT Press, 1977; 3rd Edition, Dover, 1986.