Microarray Data
This is the data is the full data set that appeared in the following publications:
Chattopadhyay, S., Ito, M., Cooper, J. D., Brooks, A. I., Curran, T. M., Powers, J. M. and Pearce, D. A. (2002). An autoantibody inhibitory to glutamic acid decarboxylase in the neurodegeneartive disorder Batten disease. Hum. Mol. Genet. 11 , 1421-1431.
Bijlani, R., Chen, Y., Brooks, A. I., Pearce D. A. and Ogihara, M. (2002). Prediction of biologically significant components from microarray data: Independently Consistent Expression Discriminator (ICED). Bioinformatics. 19, 62-70.
Brooks, A. I, Chattopadhyay, S, Mitchison, H. M, Nussbaum, R. L and Pearce, D.A. (2003). Functional Categorization of Gene Expression Changes in the Cerebellum of a Cln3-Knockout Mouse Model for Batten Disease. Mol. Gen Metab. 78, 17-30.
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This is the data is the full data set that appeared in the following publication:
Elshatory, Y, Brooks, A. I, Chattopadhyay, S, Curran, T. M, Gupta, P, Ramalingam, V, Hofmann, S. L. and Pearce, D. A. (2003). Early Changes in Gene Expression in Two Models of Batten Disease. FEBS Lett. 538, 207-212.
Results from 10 week old whole brain cln1- and cln3-knockout mice > 1-5 fold change, pvalue < 0.05.
Gene expression changes in the whole brain of cln1-knockout mice < 1-5 fold change, pvalue <0.05.
Gene expression changes in the whole brain of cln3-knockout mice < 1-5 fold change, pvalue <0.05.
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This is the data is the full data set that appeared in the following publication:
Chattopadhyay, S., Kingsley, E., Serour, A., Curran, T. M., Brooks, A. I., and Pearce, D. A. (2004). Altered Gene Expression in the Eye of a Mouse Model for Batten Disease. IOVS. 45, 2893-2905.
Eye-array, all changes (Table 1)
Eye-array, changes specific to eye (Table 2)
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