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Woeller CF, Gaspari M, Isken O, Maquat LE (2008) NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA. EMBO Rep, 9:446-51
Sato H, Hosoda N, Maquat LE (2008) Efficiency of the pioneer round of translation affects the cellular site of nonsense-mediated mRNA decay. Mol Cell, 29:255-62
Saltzman AL, Kim YK, Pan Q, Fagnani MM, Maquat LE, Blencowe BJ (2008) Regulation of multiple core spliceosomal proteins by alternative splicing-coupled nonsense-mediated mRNA decay. Mol Cell Biol,
Isken O, Kim YK, Hosoda N, Mayeur GL, Hershey JW, Maquat LE (2008) Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay. Cell, 133:314-27
Matsuda D, Hosoda N, Ki Kim Y, Maquat LE (2007) Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA. Nat Struct Mol Biol,
Kim YK, Furic L, Parisien M, Major F, Desgroseillers L, Maquat LE (2007) Staufen1 regulates diverse classes of mammalian transcripts. Embo J, 26:2670-81
Isken O, Maquat LE (2007) Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function. Genes Dev, 21:1833-56
Kuzmiak HA, Maquat LE (2006) Applying nonsense-mediated mRNA decay research to the clinic: progress and challenges. Trends Mol Med, 12:306-16
Pan Q, Saltzman AL, Kim YK, Misquitta C, Shai O, Maquat LE, Frey BJ, Blencowe BJ (2006) Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsense-mediated mRNA decay to control gene expression. Genes Dev, 20:153-8
Hosoda N, Lejeune F, Maquat LE (2006) Evidence that poly(A) binding protein C1 binds nuclear pre-mRNA poly(A) tails. Mol Cell Biol, 26:3085-97
Kim YK, Maquat LE (2006) Staufen1-mediated mRNA decay: A Upf1-dependent pathway. Nonsense-mediated mRNA decay . In: Nonsense-Mediated mRNA Decay, ed Lynne E. Maquat, Landes Bioscience, Austin, TX, pp 229-236
Maquat LE (2006) Nonsense-mediated mRNA decay in mammalian cells: A history. Nonsense-mediated mRNA decay. In: Nonsense-Mediated mRNA Decay, ed. Lynne E. Maquat, Landes Bioscience, Georgetown,TX,, pp 43-69
Hosoda N, Kim YK, Lejeune F, Maquat LE (2005) CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells. Nat Struct Mol Biol, 12:893-901
Maquat LE (2005) Nonsense-mediated mRNA decay in mammals. J Cell Sci, 118:1773-6
Gao Q, Das B, Sherman F, Maquat LE (2005) Cap-binding protein 1-mediated and eukaryotic translation initiation factor 4E-mediated pioneer rounds of translation in yeast. Proc Natl Acad Sci U S A, 102:4258-63
Lejeune F, Maquat LE (2005) Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells. Curr Opin Cell Biol, 17:309-15
Kim YK, Furic L, Desgroseillers L, Maquat LE (2005) Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay. Cell, 120:195-208
Lejeune F, Ranganathan AC, Maquat LE (2004) eIF4G is required for the pioneer round of translation in mammalian cells. Nat Struct Mol Biol, 11:992-1000
Valencia-Sanchez MA, Maquat LE (2004) An enemy within: fly reconnaissance deploys an endonuclease to destroy nonsense-containing mRNA. Trends Cell Biol, 14:594-597
Brumbaugh KM, Otterness DM, Geisen C, Oliveira V, Brognard J, Li X, Lejeune F, Tibbetts RS, Maquat LE, Abraham RT (2004) The mRNA Surveillance Protein hSMG-1 Functions in Genotoxic Stress Response Pathways in Mammalian Cells. Mol Cell, 14:585-98
Maquat LE (2004) Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics. Nat Rev Mol Cell Biol, 5:89-99
Chiu SY, Lejeune F, Ranganathan AC, Maquat LE (2004) The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex. Genes Dev, 18:745-54
Lejeune F, Maquat LE (2004) RNA Processing and Human Disorders. Encyclopedia of the Human Genome. Nature Publishing Group, in press
Maquat LE (2004) Nonsense-Mediated mRNA decay: A comparative analysis of different species. Current Genomics, 5:175-190
Lejeune F, Maquat LE (2004) Immunopurification and analysis of protein and RNA components of mRNP in mammalian cells. Methods Mol Biol, 257:115-24
Lejeune F, Li X, Maquat LE (2003) Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. Mol Cell, 12:675-87
Arraiano CM, Maquat LE (2003) Post-transcriptional control of gene expression: effectors of mRNA decay. Mol Microbiol, 49:267-76
Chiu SY, Serin G, Ohara O, Maquat LE (2003) Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1. RNA, 9:77-87
Maquat LE (2003) Nonsense-mediated mRNA decay in mammalian cells: From pre-mRNA processing to mRNA translation and degradation. Translation Mechanisms, eds Jacques Lapointe and Lea Brakier-Gingras, Landes Bioscience, Austin, TX, 213-222
Stevens A, Wang Y, Bremer K, Zhang J, Hoepfner R, Antoniou M, Schoenberg DR, Maquat LE (2002) Beta -Globin mRNA decay in erythroid cells: UG site-preferred endonucleolytic cleavage that is augmented by a premature termination codon. Proc Natl Acad Sci U S A, 99:12741-6
Maquat LE (2002) Molecular biology. Skiing toward nonstop mRNA decay. Science, 295:2221-2
Maquat LE (2002) Nonsense-mediated mRNA decay. Curr Biol, 12:R196-7
Maquat LE (2002) NASty effects on fibrillin pre-mRNA splicing: another case of ESE does it, but proposals for translation-dependent splice site choice live on. Genes Dev, 16:1743-53
Lejeune F, Ishigaki Y, Li X, Maquat LE (2002) The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling. Embo J, 21:3536-45
Maquat LE (2002) RNA-protein interactions: insight into gene function. Methods, 26:93-4
Sun X, Maquat LE (2002) Nonsense-mediated decay: assaying for effects on selenoprotein mRNAs. Methods Enzymol, 347:49-57
Maquat LE, Serin G (2002) Nonsense-mediated mRNA decay: Insights into mechanism from the cellular abundance of human Upf1, Upf2, Upf3 and Upf3X proteins. In Cold Spring Harbor Symposia on Quantitative Biology. The Ribosome, 66:313-320
Sun X, Maquat LE (2002) Nonsense-Mediated Decay: Assaying for Effects on Selenoprotein mRNAs. In Methods in Enzymology. Protein Sensors of Reactive Oxygen Species: Selenoproteins, Thioredoxin, Thiol Enzymes, and Proteins, eds. H. Sies, L. Packer, Academic Press, 347:49-57
Ishigaki Y, Li X, Serin G, Maquat LE (2001) Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20. Cell, 106:607-17 (This article was selected as Editors' Choice, Science, 2001, 293:2173.)
Maquat LE, Li X (2001) Mammalian heat shock p70 and histone H4 transcripts, which derive from naturally intronless genes, are immune to nonsense-mediated decay. Rna, 7:445-56
Denning G, Jamieson L, Maquat LE, Thompson EA, Fields AP (2001) Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein. J Biol Chem, 276:22709-14
Maquat LE, Carmichael GG (2001) Quality control of mRNA function. Cell, 104:173-6
Maquat LE (2001) The power of point mutations. Nat Genet, 27:5-6
Pal M, Ishigaki Y, Nagy E, Maquat LE (2001) Evidence that phosphorylation of human Upfl protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathway. Rna, 7:5-15
Serin G, Gersappe A, Black JD, Aronoff R, Maquat LE (2001) Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4). Mol Cell Biol, 21:209-23
Schneider R, Agol VI, Andino R, Bayard F, Cavener DR, Chappell SA, Chen JJ, Darlix JL, Dasgupta A, Donze O, Duncan R, Elroy-Stein O, Farabaugh PJ, Filipowicz W, Gale MJr, Gehrke L, Goldman E, Groner Y, Harford JB, Hatzglou M, He B, Hellen CU, Hentze MW, Hershey J, Hershey P, Hohn T, Holcik M, Hunter CP, Igarashi K, Jackson R, Jagus R, Jefferson LS, Joshi B, Kaempfer R, Katze M, Kaufman RJ, Kiledjian M, Kimball SR, Kimchi A, Kirkegaard K, Koromilas AE, Krug RM, Kruys V, Lamphear BJ, Lemon S, Lloyd RE, Maquat LE, Martinez-Salas E, Mathews MB, Mauro VP, Miyamoto S, Mohr I, Morris DR, Moss EG, Nakashima N, Palmenberg A, Parkin NT, Pe'ery T, Pelletier J, Peltz S, Pestova TV, Pilipenko EV, Prats AC, Racaniello V, Read GS, Rhoads RE, Richter JD, Rivera-Pomar R, Rouault T, Sachs A, Sarnow P, Scheper GC, Schiff L, Schoenberg DR, Semler BL, Siddiqui A, Skern T, Sonenberg N, Tahara SM, Thomas AA, Toulme JJ, Wilusz J, Wimmer E, Witherell G, Wormington M (2001) New ways of initiating translation in eukaryotes. Mol Cell Biol, 21:8238-46
Sun X, Li X, Moriarty PM, Henics T, LaDuca JP, Maquat LE (2001) Nonsense-mediated decay of mRNA for the selenoprotein phospholipid hydroperoxide glutathione peroxidase is detectable in cultured cells but masked or inhibited in rat tissues. Mol Biol Cell, 12:1009-17
Maquat LE, Serin G (2001) Nonsense-mediated mRNA decay: insights into mechanism from the cellular abundance of human Upf1, Upf2, Upf3, and Upf3X proteins. Cold Spring Harb Symp Quant Biol, 66:313-20
Maquat LE (2001) Evidence that selenium deficiency results in the cytoplasmic decay of GPx1 mRNA dependent on pre-mRNA splicing proteins bound to the mRNA exon-exon junction. Biofactors, 14:37-42
Sun X, Moriarty PM, Maquat LE (2000) Nonsense-mediated decay of glutathione peroxidase 1 mRNA in the cytoplasm depends on intron position. Embo J, 19:4734-44
Le Hir H, Moore MJ, Maquat LE (2000) Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions. Genes Dev, 14:1098-108
Valentin C, Cohen-Solal M, Maquat L, Horanyi M, Inselt-Kovacs M, Hollan S (2000) Identical germ-line mutations in the triosephosphate isomerase alleles of two brothers are associated with distinct clinical phenotypes. C R Acad Sci III, 323:245-50
Sun X, Maquat LE (2000) mRNA surveillance in mammalian cells: the relationship between introns and translation termination. Rna, 6:1-8
Le Hir H, Izaurralde E, Maquat LE, Moore MJ (2000) The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions. Embo J, 19:6860-9
Zhang J, Sun X, Qian Y, LaDuca JP, Maquat LE (1998) At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translation. Mol Cell Biol, 18:5272-83
Moriarty PM, Reddy CC, Maquat LE (1998) Selenium deficiency reduces the abundance of mRNA for Se-dependent glutathione peroxidase 1 by a UGA-dependent mechanism likely to be nonsense codon-mediated decay of cytoplasmic mRNA. Mol Cell Biol, 18:2932-9
Nagy E, Maquat LE (1998) A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance. Trends Biochem Sci, 23:198-9
Zhang J, Sun X, Qian Y, Maquat LE (1998) Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm. Rna, 4:801-15
Sun X, Perlick HA, Dietz HC, Maquat LE (1998) A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells. Proc Natl Acad Sci U S A, 95:10009-14
Zhang J, Maquat LE (1997) Evidence that translation reinitiation abrogates nonsense-mediated mRNA decay in mammalian cells. Embo J, 16:826-33
Moriarty PM, Reddy CC, Maquat LE (1997) The presence of an intron within the rat gene for selenium-dependent glutathione peroxidase 1 is not required to protect nuclear RNA from UGA-mediated decay. Rna, 3:1369-73
Zhang J, Maquat LE (1996) Evidence that the decay of nucleus-associated nonsense mRNA for human triosephosphate isomerase involves nonsense codon recognition after splicing. Rna, 2:235-43
Maquat LE (1996) Defects in RNA splicing and the consequence of shortened translational reading frames. Am J Hum Genet, 59:279-86
Stephenson LS, Maquat LE (1996) Cytoplasmic mRNA for human triosephosphate isomerase is immune to nonsense-mediated decay despite forming polysomes. Biochimie, 78:1043-7
Maquat LE (1995) When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells. Rna, 1:453-65
Nesic D, Zhang J, Maquat LE (1995) Lack of an effect of the efficiency of RNA 3'-end formation on the efficiency of removal of either the final or the penultimate intron in intact cells. Mol Cell Biol, 15:488-96
Belgrader P, Maquat LE (1994) Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping. Mol Cell Biol, 14:6326-36
Cheng J, Belgrader P, Zhou X, Maquat LE (1994) Introns are cis effectors of the nonsense-codon-mediated reduction in nuclear mRNA abundance. Mol Cell Biol, 14:6317-25
Nesic D, Maquat LE (1994) Upstream introns influence the efficiency of final intron removal and RNA 3'-end formation. Genes Dev, 8:363-75
Belgrader P, Cheng J, Zhou X, Stephenson LS, Maquat LE (1994) Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life. Mol Cell Biol, 14:8219-28
Cheng J, Maquat LE (1993) Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA. Mol Cell Biol, 13:1892-902
Chang ML, Artymiuk PJ, Wu X, Hollan S, Lammi A, Maquat LE (1993) Human triosephosphate isomerase deficiency resulting from mutation of Phe-240. Am J Hum Genet, 52:1260-9
Nesic D, Cheng J, Maquat LE (1993) Sequences within the last intron function in RNA 3'-end formation in cultured cells. Mol Cell Biol, 13:3359-69
Belgrader P, Cheng J, Maquat LE (1993) Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA. Proc Natl Acad Sci U S A, 90:482-6
Lim SK, Maquat LE (1992) Human beta-globin mRNAs that harbor a nonsense codon are degraded in murine erythroid tissues to intermediates lacking regions of exon I or exons I and II that have a cap-like structure at the 5' termini. Embo J, 11:3271-8
Lim SK, Sigmund CD, Gross KW, Maquat LE (1992) Nonsense codons in human beta-globin mRNA result in the production of mRNA degradation products. Mol Cell Biol, 12:1149-61
Boyer TG, Maquat LE (1991) Modulation of human triosephosphate isomerase gene transcription by serum. J Biol Chem, 266:13350-4
Maquat LE (1991) Nuclear mRNA export. Curr Opin Cell Biol, 3:1004-12
Cheng J, Fogel-Petrovic M, Maquat LE (1990) Translation to near the distal end of the penultimate exon is required for normal levels of spliced triosephosphate isomerase mRNA. Mol Cell Biol, 10:5215-25
Boyer TG, Maquat LE (1990) Minimal sequence and factor requirements for the initiation of transcription from an atypical, TATATAA box-containing housekeeping promoter. J Biol Chem, 265:20524-32
Cheng J, Mielnicki LM, Pruitt SC, Maquat LE (1990) Nucleotide sequence of murine triosephosphate isomerase cDNA. Nucleic Acids Res, 18:4261
Lim S, Mullins JJ, Chen CM, Gross KW, Maquat LE (1989) Novel metabolism of several beta zero-thalassemic beta-globin mRNAs in the erythroid tissues of transgenic mice. Embo J, 8:2613-9
Boyer TG, Krug JR, Maquat LE (1989) Transcriptional regulatory sequences of the housekeeping gene for human triosephosphate isomerase. J Biol Chem, 264:5177-87
Daar IO, Maquat LE (1988) Premature translation termination mediates triosephosphate isomerase mRNA degradation. Mol Cell Biol, 8:802-13
Daar IO, Artymiuk PJ, Phillips DC, Maquat LE (1986) Human triose-phosphate isomerase deficiency: a single amino acid substitution results in a thermolabile enzyme. Proc Natl Acad Sci U S A, 83:7903-7
Baumann H, Maquat LE (1986) Localization of DNA sequences involved in dexamethasone-dependent expression of the rat alpha 1-acid glycoprotein gene. Mol Cell Biol, 6:2551-61
Maquat LE, Chilcote R, Ryan PM (1985) Human triosephosphate isomerase cDNA and protein structure. Studies of triosephosphate isomerase deficiency in man. J Biol Chem, 260:3748-53
Brown JR, Daar IO, Krug JR, Maquat LE (1985) Characterization of the functional gene and several processed pseudogenes in the human triosephosphate isomerase gene family. Mol Cell Biol, 5:1694-706
Maquat LE, Kinniburgh AJ (1985) A beta zero-thalassemic beta-globin RNA that is labile in bone marrow cells is relatively stable in HeLa cells. Nucleic Acids Res, 13:2855-67
Kinniburgh AJ, Maquat LE, Schedl T, Rachmilewitz E, Ross J (1982) mRNA-deficient beta o-thalassemia results from a single nucleotide deletion. Nucleic Acids Res, 10:5421-7
Maquat LE, Kinniburgh AJ, Rachmilewitz EA, Ross J (1981) Unstable beta-globin mRNA in mRNA-deficient beta o thalassemia. Cell, 27:543-53
Maquat LE, Thornton K, Reznikoff WS (1980) lac Promoter mutations located downstream from the transcription start site. J Mol Biol, 139:537-49
Maquat LE, Reznikoff WS (1980) lac Promoter mutation Pr115 generates a new transcription initiation point. J Mol Biol, 139:551-6
Maquat LE, Kinniburgh AJ, Beach LR, Honig GR, Lazerson J, Ershler WB, Ross J (1980) Processing of human beta-globin mRNA precursor to mRNA is defective in three patients with beta+-thalassemia. Proc Natl Acad Sci U S A, 77:4287-91
Patient RK, Hardies SC, Larson JE, Inman RB, Maquat LE, Wells RD (1979) Influence of A-T content on the fractionation of DNA restriction fragments by RPC-5 column chromatography. J Biol Chem, 254:5548-54
Maquat LE, Reznikoff WS (1978) In vitro analysis of the Escherichia coli RNA polymerase interaction with wild-type and mutant lactose promoters. J Mol Biol, 125:467-90
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