Kielkopf Lab Publications

Swenson, M.S., Paranawithana, S.R., Miller, P.S. and Kielkopf, C.L. (2007) Structure of a DNA Repair Substrate Containing an Alkyl Interstrand Crosslink at 1.65 Resolution. Biochemistry. 46, 4545-4553.

Thickman, K., Sickmier, E.A. and Kielkopf, C.L. (2007) Alternative conformations at the RNA binding surface of the N-terminal U2AF⁶⁵ RNA recognition motif. J. Mol. Biol. 366, 703-710.

Sickmier, E.A., Frato, K.E., Paranawithana, S., Shen, H. Green, M.R. and Kielkopf, C.L. (2006) Structural basis of polypyrimidine tract recognition by the essential splicing factor U2AF⁶⁵. Mol. Cell 23, 49-59.

Sickmier, E.A., Frato K.E., and Kielkopf, C.L. (2006) Crystallization and preliminary X-ray analysis of a U2AF⁶⁵ variant in complex with a polypyrimidine-tract analogue by use of protein engineering. Acta Cryst. F62, 457-459.

Manceau, V., Swenson, M., LeCaer, J.P., Sobel, A., Kielkopf, C.L., and Maucuer, A. (2006) Major Phosphorylation of SF1 on Adjacent Ser-Pro Motifs Enhances Interaction with U2AF⁶⁵. FEBS J. 273, 577-87.

Thickman, K.R., Swenson, M., Gryczynski, Z., and Kielkopf, C.L. (2006) Multiple U2AF⁶⁵ binding sites within SF3b155: Thermodynamic and spectroscopic characterization of protein-protein interactions by pre-mRNA splicing factor complexes. J. Mol. Biol. 356, 664-683.

Sickmier, E.A., Brekasis, D., Paranawithana, S., Bonanno, J.B., Paget, M.S.B., Burley, S.K., and Kielkopf, C.L. (2005) X-ray Structure of a Rex-Family Repressor/NADH Complex: Insights into the Mechanism of Redox Sensing. Structure. 13, 43-54.

Kielkopf, C.L., Rodionova, N.A., Green, M.R., and Burley, S.K. (2001) A novel peptide recognition mode revealed by the X-ray structure of a core U2AF³⁵/U2AF⁶⁵ heterodimer, Cell 106, 595-605. (as postdoctoral scholar)

Review Articles:

Kielkopf, C.L., Luecke, S., and Green, M.R. (2004) U2AF-Homology-Motifs: Protein Recognition in the RRM World, Genes & Dev. 18, 1513-1526. (Peer-reviewed)

	Kielkopf Laboratory Publications
	Primary Research Publications: Swenson, M.S., Paranawithana, S.R., Miller, P.S. and Kielkopf, C.L. (2007) Structure of a DNA Repair Substrate Containing an Alkyl Interstrand Crosslink at 1.65 Resolution. Biochemistry. 46, 4545-4553. Thickman, K., Sickmier, E.A. and Kielkopf, C.L. (2007) Alternative conformations at the RNA binding surface of the N-terminal U2AF⁶⁵ RNA recognition motif. J. Mol. Biol. 366, 703-710. Sickmier, E.A., Frato, K.E., Paranawithana, S., Shen, H. Green, M.R. and Kielkopf, C.L. (2006) Structural basis of polypyrimidine tract recognition by the essential splicing factor U2AF⁶⁵. Mol. Cell 23, 49-59. Sickmier, E.A., Frato K.E., and Kielkopf, C.L. (2006) Crystallization and preliminary X-ray analysis of a U2AF⁶⁵ variant in complex with a polypyrimidine-tract analogue by use of protein engineering. Acta Cryst. F62, 457-459. Manceau, V., Swenson, M., LeCaer, J.P., Sobel, A., Kielkopf, C.L., and Maucuer, A. (2006) Major Phosphorylation of SF1 on Adjacent Ser-Pro Motifs Enhances Interaction with U2AF⁶⁵. FEBS J. 273, 577-87. Thickman, K.R., Swenson, M., Gryczynski, Z., and Kielkopf, C.L. (2006) Multiple U2AF⁶⁵ binding sites within SF3b155: Thermodynamic and spectroscopic characterization of protein-protein interactions by pre-mRNA splicing factor complexes. J. Mol. Biol. 356, 664-683. Sickmier, E.A., Brekasis, D., Paranawithana, S., Bonanno, J.B., Paget, M.S.B., Burley, S.K., and Kielkopf, C.L. (2005) X-ray Structure of a Rex-Family Repressor/NADH Complex: Insights into the Mechanism of Redox Sensing. Structure. 13, 43-54. Kielkopf, C.L., Rodionova, N.A., Green, M.R., and Burley, S.K. (2001) A novel peptide recognition mode revealed by the X-ray structure of a core U2AF³⁵/U2AF⁶⁵ heterodimer, Cell 106, 595-605. (as postdoctoral scholar) Review Articles: Kielkopf, C.L., Luecke, S., and Green, M.R. (2004) U2AF-Homology-Motifs: Protein Recognition in the RRM World, Genes & Dev. 18, 1513-1526. (Peer-reviewed)