1. Potter, D.I., Epstein, H.D. and Goldstein, B.M. Metastable and Equilibrium Phases in Dilute V&endash;N Alloys. Metallurgical Transactions, 5: 2075&endash;2082 (1974).
2. Goldstein, B.M. Disorder in the Structure of Trisodium Phosphorothioate Dodecahydrate. Acta. Cryst. B38:1116-1120 (1982).
3. Goldstein, B.M., Takusagawa, F., Berman, H.M., Srivastava, P.C. and Robins, R.K. Structural Studies of a New Antitumor Agent: Tiazofurin and its Inactive Analogues. J. Am. Chem. Soc. 105:7416-7422 (1983).
4. Takusagawa, F., Goldstein, B.M., Youngster, S., Jones, R. and Berman, H.M Crystallization and Preliminary X-ray Study of a Complex Between d(ATGCAT) and Actinomycin D. J. Biol. Chem. 259: 4714-4715 (1984).
5. Goldstein, B.M., Takusagawa, F., Berman, H.M., Srivastava, P.C. and Robins, R.K. Structural Studies of a New Antitumor and Antiviral Agent: Selenazofurin and Its Alpha-Anomer. J. Am. Chem. Soc. 107: 1394-1400 (1985).
6. Goldstein, B.M., Barton, J., Berman, H.M. Crystal and Molecular Structure of a Chiral-Specific DNA Binding Agent: tris(4,7-diphenylphenanthroline) ruthenium (II). J. Inorg. Chem. 25: 842-847 (1986).
7. Goldstein, B.M., Takusagawa, F., Srivastava, P.C. and Knapp, F. Cis/trans Disorder in (5-Bromo-4-Pentenyl) triphenylphosphonium Iodide. Acta Cryst. C42: 570-573 (1986).
8. Banerjee, A., Levy, H.R., Levy, G.C., LiMuti, C., Goldstein, B.M., Bell, J.E. A TRNOE Study of Coenzyme Binding to Distinct Sites in Binary and Ternary Complexes in Glutamate Dehydrogenase. Biochemistry 26:8443-8449 (1987).
9. Goldstein, B.M. Introduction to the Crystallographic Literature: A Course for the Non-specialist. J. Chem. Ed. 65:508-512 (1988).
10. Goldstein, B.M., Marquez, V.E. and Mao, D.A. Ara-Tiazofurin: Conservation of Structural Features in an Unusual Thiazole Nucleoside. J. Med. Chem.31:1026-1031 (1988).
11. Tsing, C., Marquez,, V.E., Driscoll, J.S., Fuller, R.F., Goldstein, B.M., Haines, D.R., Parsons, J.L., Shannon, V.N., Arnett, G. and Hollingshead, M. Synthesis of 3-deazaneplanocin A: A Powerful Inhibitor of 5-adenosylhomocysteine Hydrolase with Potent and Selective In Vitro and In Vivo Antiviral Activities. J. Med. Chem. 32:1442-1446 (1989).
12. Goldstein, B.M., Bell, J.E. and Marquez, V.E. Dehydrogenase Binding by Tiazofurin Anabolites. J. Med. Chem. 33: 1123-1127 (1990).
13. Goldstein, B.M., Kennedy, S.D. and Hennen, W.J. 77Se NMR and Crystallographic Studies of Selenazofurin and its 5-amino Derivative. J. Am. Chem. Soc.112:8265-8268 (1990).
14. Srivastava,P.C., Knapp, F.F. Jr.,Callahan, A.P. and Goldstein, B.M. Myocardial Imaging Agents: Synthesis, Characterization and Evaluation of [(Z) and (Z,E)-(1-[82Br]Bromo-1-penten-5-yl)] triphenylphosphonium Cations. J. Labeled Comp. and Radiopharm., 28: 1161-1169 (1991).
15. *Burling, F.T., Gabrielson, B., and Goldstein, B.M. Structures of the 2',3'-dideoxy and 2',3'-didehydro Analogues of Tiazofurin. Acta Cryst. C47:1272-1275 (1991).
16. Goldstein, B.M., Leary, J.F., Farley, B.A., Marquez, V.E., Levy, P. and Rowley, P.T. Induction of HL60 Cell Differentiation by Tiazofurin and its Analogues: Characterization and Efficacy. Blood. 78:593-598 (1991).
17. Zhen,W., Jayaram, H.N., Marquez,V.E., Goldstein,B.M., Cooney,D.A., Weber,G. Cytotoxicity of Tiazofurin and its Arabinose and Xylose Analogues in K562 Cells. Biochem. Biophys. Res. Commun., 180:933-938 (1991).
18. Bodenteich, M.; Marquez, V.E., *Hallows, W.H., Goldstein, B.M. Synthesis and Structural characterization of (±) Neplanocin F. J. Org. Chem. , 57:2071-2076 (1992)
19. *Burling, F.T., Goldstein, B.M. Computational Studies of Nonbonded Sulfur-Oxygen and Selenium-Oxygen Interactions in the Thiazole and Selenazole Nucleosides. J. Am. Chem. Soc., 114:2313-2320 (1992)
20. *Burling, F.T., *Hallows, W.H., Gabrielsen, B., Goldstein, B.M. Structures of the 4-Cyano and 4-Methylamidate Analogs of Tiazofurin. Acta Crystallogr. Part B, 48:677-683 (1992).
21. *Li, H.; Goldstein, B. M. Carboxamide Conformation in the Nicotinamide and Thiazole -4-carboxamide Rings: Implications for Dehydrogenase Binding. J. Med. Chem., 35:3560-3567 (1992). Medline Abstract
22. *Li, H.;Kennedy, S., Goldstein, B. M. The Solid State and Solution Conformations of Isotiazofurin: Crystallographic, Computational and 1H NMR Studies. Acta Cryst. Part B.,49: 729-738 (1993).
23. *Burling, F.T., Goldstein, B.M. A Database Study of Non-Bonded Intramolecular Sulfur-Nucleophile Contacts. Acta Cryst. Part B.,B49: 738-744 (1993).
24. Pankiewicz, K. W., Zeidler, J., Ciszewski, L. A., Bell, J. E., Goldstein, B. M. Jayaram, H. N., Watanabe, K. A. Synthesis of Isosteric C-Nucleotide Analogues of Nicotinamide Adenine Dinucleotide Containing C-Nucleotide of Nicotinamide or Picolinamide. J. Med. Chem., 36: 1855-1859 (1993).
25. Zatorski, A., Lipka, P., Mollova, N., Schram, K. H., Goldstein, B.M., Watanabe, K.A., Pankiewicz, K.W. Synthesis of Thiazole-4-carboxamide-adenine Difluoromethylenediposphonates Substituted with Fluorine at the C-2' of the Adenosine Ribose. Carbohyd. Res., 249:95-108 (1993).
26. Bodenteich, M., Marquez, Barchi, J.J. Jr., *Hallows, W.H., Goldstein, B.M., Driscoll, J.S. Synthesis of Carbocyclic Analogues of 1-beta-D-Psicoofuranosyl Nucleosides. Psico-cyclopentenyladenosine (Psicoplanocin A) and Psico-cyclopentenylcytosine. J. Org. Chem., 58: 6009-6015 (1993).
27. *Li, H. , *Hallows, W. A., *Punzi, J. S., Marquez, V. E., Carrell, H.L., Pankiewicz, K.W., Watanabe, K. A., Goldstein, B.M. Crystallographic Studies of Two Alcohol Dehydrogenase-bound Analogues of Thiazole-4-Carboxamide Adenine Dinucleotide (TAD), the Active Anabolite of the Antitumor Agent Tiazofurin. Biochemistry. 33: 23-32 (1994). Medline Abstract
28. Goldstein, B.M., *Li, H., *Hallows, W.H., Langs,D.A., Franchetti, P., Cappellacci, L., Grifantini, M. C-glycosyl Bond Conformation in Oxazofurin: Crystallographic and Computational Studies of the Oxazole Analogue of Tiazofurin. J. Med. Chem.37:1684-1688 (1994).
29. Goldstein, B.M., *Li, H., Jones, J.P., Bell, J.E., Zeidler, J., Watanabe, K.A., Pankiewicz, K.W. CNAD: A Potent and Specific Inhibitor of Alcohol Dehydrogenase. J. Med. Chem. 37:392-399 (1994).
30. *Li, H., *Punzi, J. S., *Hallows, W. A., Pankiewicz, K.W., Watanabe, K. A., Goldstein, B.M. Crystallographic Studies of Isosteric NAD Analogues Bound to Alcohol Dehydrogenase: Specificity and Substrate Binding in Two Ternary Complexes. Biochemistry, 33: 11734-11744 (1994). Medline Abstract
31. Zatorski, A., Goldstein, B.M., *Colby, T. D., Jones, J. P., Pankiewicz, K. W. Potent Inhibitors of Human Inosine Monophosphate Dehydrogenase Type-II: Flourine-Substituted Analogues of Thiazole-4-Carboxamide-Adenine Dinucleotide. J. Med. Chem, 38: 1098- 1105 (1995).
32. Franchetti, P., Cappellacci, L., Grifantini, M., Barzi, A, Nocenti, G., Yang, H., O'Connor, A., Jayaram, H. N., Carrell, C., Goldstein, B.M. Furanfurin and Thiophenfurin: Two Novel Tiazofurin Analogues. Synthesis, Structure, Antitumor Activity, and Interactions with Inosine Monophosphate Dehydrogenase. J. Med. Chem., 39: 3829-3837 (1995).
33. Cappellacci, L., Franchetti, P., Grifantini, M., Messini, L., Abu Sheikha, G., Nocenti, G., Moraca, R., Goldstein, B.M. Synthesis, Antitumor Activity and Crystallographic Studies of Analogues of Tiazofurin. Nucleosides and Nucleotides, 14:637-640 (1995).
34. Zatorski, A., Watanabe, K. A., Carr, S. F., Goldstein, B.M., Pankiewicz, K. W. The Chemical Synthesis of Benzamide Adenine Dinucleotide: Inhibition of Inosine Monophosphate Dehydrogenase (Type I and II) J. Med. Chem. 39: 2422-2426 (1996) . REPRINT *
35. Zatorski, A., Watanabe, K. A., *Colby, T.D., Goldstein, B.M., Carr, S. F., Pankiewicz, K. W. The Practical Synthesis of Methylene Bisphosphonate Analogue of Benzamide Adenine Dinucleotide. Inhibition of Human Inosine Monophosphate Dehydrogenase Type I and II. J. Med. Chem. 40: 1287-1291 (1997) . REPRINT *
36. Franchetti, P., Cappellacci, L., Abu Sheikha, G., Jayaram, H. N., Gurudutt, V.V., Sint, T., Schneider, B.P., Jones, W.D., Goldstein, B.M., Perra, G., Poma, S., La Colla, P., Grifantini, M. Structure-Activity Studies of C-Nucleoside Analogs of Tiazofurin and Selenazofurin: Synthesis, Structure, and Antiproliferative Activity of Selenophenfurin, an Inosine 5'-Monophosphate Dehydrogenase Inhibitor Analogue of Selenazofurin. J. Med. Chem. , 40:1731-1737, (1997).
37. Lesiak, K; Watanabe, K. A., Majumdar, A., Seidman, M., *Vanderveen, K., Goldstein, B. M., Pankiewicz, K. W. Synthesis of Non-hydrolyzable Analogues of Thiazole-4-carboxamide- and Benzamidine-Adenine Dinucleotide . Induction of K562 Differentiation and IMPDH Inhibitory Activity J. Med. Chem. , 40:2533-2538, (1997). REPRINT *
38. Bahnson, B. J., *Colby, T. D., Chin, J., Goldstein, B. M., Klinman, J. P. A link Between Protein Structure and Enzyme Catalyzed Hydrogen Tunneling. Proc. Nat. Acad. Sci. , 94: 12797-12802 (1997) . REPRINT *
39. Lesiak, K; Watanabe, K. A., Majumdar, A., Powell, J., Seidman, M., *Vanderveen, K., Goldstein, B. M., Pankiewicz, K. W. Synthesis of Methylene Bis(phosphonate) Analogue of Mycophenolic Adenine Dinucleotide. A Glucuronidation Resistant MAD Analogue of NAD. J. Med. Chem. , 41:618-622 (1998) . REPRINT *
40. *Colby, T. D.; Bahnson, B. J., , Chin, J., Klinman, J. P.; Goldstein, B. M. Active Site Modifications in a Double Mutant of Liver Alcohol Dehydrogenase: Structural Studies of Two Enzyme-ligand Complexes. Biochemistry , 37:9295-9304 (1998) . REPRINT*
41. *Colby, T. D., *Vanderveen, K., *Strickler, M.D., Markham, G. D., Goldstein, B.M. Crystal Structure of Human Type II Inosine Monophosphate dehydrogenase: Implications for ligand binding and drug design. Proc. Nat. Acad. Sci. 96: 3531-3536 (1999) . REPRINT*
42. Franchetti, P., Marchetti, S., Cappellacci, L., Jayaram, H. N., , Yalowitz, J.A., Goldstein, B.M., Barascut, J.-L., Dukhan, D., Imbach, J.-L., Grifantini, M. Synthesis, Conformational Analysis, and Biological Activity of C-Thioribonucleosides Related to Tiazofurin. J. Med. Chem. ,43: 1260-1270 (2000). REPRINT*
Invited Reviews
Goldstein, B.M. and *Colby, T.D. IMP Dehydrogenase : Structural Aspects of Inhibitor Binding. Currrent Med. Chem. 6:519-536 (1999). Medline Abstract
Goldstein, B.M. and *Colby, T.D. Conformational Constraints in NAD Analogs: Implications for Dehydrogenase Binding and Specificity. Advances in Enzyme Regulation, 40:405-426 (2000)
Patents
Watanabe, K. A., Pankiewicz, K. W., Goldstein, B. M., Bell, J. E. C-Nucleoside Isosters of Analogs Thereof and Pharmaceutical Compositions. United States Patent 5,569,650; October 29, 1996.
Watanabe, K. A., Pankiewicz, K. W., Goldstein, B. M., Bell, J. E. Analogues of adenosine 5'diphosphate and pharmaceutical compositions thereof. United States Patent 5,700,786; Dec. 23, 1997
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