Yuriy V. Razskazovskiy
Department of Biochemistry and Biophysics, Box 712
University of Rochester School of Medicine and Dentistry
Rochester, NY 14642
raiskazy@access.etsu.edu
Academic Qualifications
|
Ph.D. in Physical Chemistry, 1984 Moscow State University, Department of Chemistry, Moscow, Russia
B. S. in Chemistry, 1980 |
| 2002-present |
Assistant Professor Department of Physics, East Tennessee State University, Johnson City, TN |
| 1998-2002 |
Research Assistant Professor Department of Biochemistry and Biophysics, University of Rochester, Rochester, NY |
| 1997-1998 |
Researcher Department of Chemistry, Oakland University, Rochester, MI |
| 1994-1997 |
Post Doctoral Research Associate Department of Chemistry, Oakland University, Rochester, MI |
| 1991-1994 |
Senior Research Scientist Department of Chemistry, Moscow State University, Moscow, Russia |
| 1984-1991 |
Research Associate Department of Chemistry, Moscow State University, Moscow, Russia |
| 1999 |
RRS Travel Award for the XI International Congress of Radiation Research, Dublin, Ireland |
| 1997 |
Young Investigator Travel Award for the International Workshop "Radiation Damage to DNA: Techniques, Quantitation and Mechanisms", Great Britain |
to January 2003 |
"Solid State Radiation Chemistry of DNA" (Investigates the free radical mechanisms that lead to direct damage in DNA exposed to ionizing radiation.) Principal Investigator: William A. Bernhard, Agency: National Cancer Institute, Type: R01 (CA32546, Years 23-28) The long-term objective of this project is to determine the mechanisms by which ionizing radiation, through direct effects, alters the primary structure of DNA in vivo. The specific aims examine free radical processes initiated in DNA by direct ionization. These aims are: (1) identify the critical factors underlying free radical trapping in DNA, (2) form a mechanistic link between diamagnetic damage and free radical intermediates, (3) find out if guanine locations correlate with strand break location, and (4) determine the outermost boundaries in the DNA hydration layer for electron and hole transfer to DNA. The approach is to use electron paramagnetic resonance spectroscopy (EPR) to study free radical intermediates formed in oligodeoxynucleotides and DNA. Oligodeoxynucleotides are studied in single crystal and polycrystalline form and DNA is studied in the form of films. |
M. G. Debije, Y. Razskazovskiy and W. A. Bernhard. (2001) The yield of strand breaks resulting from direct-type effects in crystalline DNA X-irradiated at 4 K and room temperature. J. Am. Chem. Soc. 123: 2917-2918.
Y. Razskazovskiy, M. Roginskaya, A. Jacobs and M. D. Sevilla. (2000) Reductively activated cleavage of DNA mediated by o,o'-diphenylenehalonium compounds. Rad. Res. 154: 319-325.
Y. Razskazovskiy, M. G. Debije and W. A. Bernhard. (2000) Direct radiation damage to crystalline DNA: What is the source of unaltered base release? Rad. Res. 153: 436-441.
A. Messer, K. Carpenter, K. Forzley, J. Buchanan, S. Yang, Y. Razskazovkii, Z. Cai and M. D. Sevilla. (2000) Electron Spin Resonance study of electron transfer rates in DNA: Determination of the tunneling constant beta for single step excess electron transfer. J. Phys. Chem. 104: 1128-1136.
Bernhard, W. A., M. G. Debije, M. T. Milano and Y. Razskazovskiy. (2000) Influence of structure on electron and hole transfer in directly ionized DNA. Proceedings of the Eleventh International Congress of Radiation Research, M Moriarty, C. Mothersill, C. Seymour, M. Edington, J. F. Ward, and R. J. M. Fry, eds., Vol. 2: 321-324. Y. V. Razskazovskii, M. J. Raiti and M. D. Sevilla. (1999) Electron spin resonance and molecular oribtal study of one-electron-reduced o,o'-diphenylenehalonium cations: First evidence for a diaryliodine radical, Ar2I, or simply a new sigma*-radical? J. Phys. Chem. A 103: 6351-6359. Y. V. Razskazovskii, D. Becker and M. D. Sevilla. (1999) Sulfoxyl radicals: formation, structure and kinetics. S-Centered radicals, Z. B. Alfassi, ed., Vol.: 245-276. John Wiley & Sons, Chichester - New York - Weinheim - Brisbane - Singapore - Toronto. Y. V. Razskazovskii, and M. Y. Mel'nikov. (1999) Reactions of thiyl radicals in the solid phase. S-Centered radicals, Z. B. Alfassi, ed., Vol.: 225-244. John Wiley & Sons, Chichester - New York - Weinheim - Brisbane - Singapore - Toronto.
Y. Razskazovskii, M. Roginskaya and M. D. Sevilla. (1998) Modification of the reductive pathway in gamma-irradiated DNA by electron scavengers: targeting the sugar-phosphate backbone. Radiat. Res. 149: 422-432.
W. Wang, Y. Razskazovskii and M. D. Sevilla. (1997) Secondary radical attack on DNA nucleotides: reaction by addition to DNA bases and abstraction from sugar. Int. J. Radiat. Biol. 71: 387-399.
M. D. Sevilla, D. Becker and Y. Razskazovskii. (1997) Electron and hole transfer within DNA and its hydration layer. Abstr. Pap. Am. Chem. Soc. 214: 171-Phys, Part 172. Y. Razskazovskii, S. G. Swarts, J. M. Falcone, C. Taylor and M. D. Sevilla. (1997) Competitive electron scavenging by chemically modified pyrimidine bases in bromine-doped DNA: relative efficiencies and relevance to intrastrand electron migration distances. J. Phys. Chem. 101: 1460-1467. D. Becker, Y. Razskazovskiy, M. U. Callaghan and M. D. Sevilla. (1996) Electron spin resonance of DNA irradiated with a heavy-ion beam (O-16(8+)): Evidence for damage to the deoxyribose phosphate backbone. Radiat. Res. 146: 361-368.
Y. Razskazovskii, and M. D. Sevilla. (1996) Reactions of Sulfonyl Peroxyl Radicals with DNA and its Components: Hydrogen Abstraction from the Sugar Backbone versus Addition to Pyrimidine Double Bonds. Int. J. Radiat. Biol. 69: 75-87.
Y. Razskazovskii, and M. D. Sevilla. (1996) One-electron oxidation and reduction of sulfites and sulfinic acids in oxygenated media: the formation of sulfonyl and sulfuranyl peroxyl radicals. J. Phys. Chem. 100: 4090-4096. Y. Razskazovskii, A.-O. Colson and M. D. Sevilla. (1995) On the nature of thiyl peroxyl radical: ESR and ab initio MO evidence for intermolecular stabilization of the charge transfer state, RS(+)OO-. J. Phys. Chem. 99: 7993-8001. Y. V. Razskazovskii, M. V. Roginskaya and M. Y. Melnikov. (1994) Two pathways of SO2 addition to carbon-centered free radicals grafted to a silica surface - sulfonyl and oxysulfinyl radical formation. J. Phys. Chem. 98: 12003-12007. Y. V. Razskazovskii, and M. Y. Mel'nikov. (1992) ESR spectra and reactivity of thioperoxyl radicals in low temperature glasses. Sov. J. Chem. Phys. 10: 148-156. |
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