Steven Gregory Swarts
Environmental Science Center
Syracuse Research Corporation
6225 Running Ridge Road
North Syracuse, NY 13212
(315) 452-8452
swarts@syrres.com
Academic Qualifications
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Ph.D. in Biomedical Science , 1987 Oakland University, Rochester, MI
B.S. in Chemistry 1982 |
| 2001-Present |
Senior Scientist, Environmental Science Center Syracuse Research Corporation, 6225 Running Ridge Road, North Syracuse, New York 13212 |
| 2001-Present |
Adjunct Clinical Associate Professor, Department of Radiation Oncology Wake Forest University School of Medicine, Winston-Salem, NC 27157 |
| 1999-2001 |
Acting Section Head, Radiobiology Section, Department of Radiation Oncology Wake Forest University School of Medicine, Winston-Salem, NC 27157 |
| 1999-2001 |
Consultant/Subcontractor Syracuse Research Corporation, 6225 Running Ridge Road, North Syracuse, New York 13212 |
| 1997-2001 |
Research Associate Professor, Department of Radiation Oncology Wake Forest University School of Medicine, Winston-Salem, NC 27157 |
| 1996-1997 |
Research Associate Professor, Department of Radiation Oncology, Division of Radiologic Sciences Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC |
| 1994-1996 |
Research Associate Professor, Department of Radiation Oncology, Division of Radiologic Sciences Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC |
| 1990-1994 |
Research Associate Professor, Department of Radiation Oncology, Division of Radiologic Sciences Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC |
| 1987-1990 |
Research Fellow, Experimental Radiation Oncology, Department of Radiology Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC |
| 1983-1987 |
Graduate Assistant Department of Chemistry, Oakland University, Rochester, Michigan |
| 1983-1987 |
Teaching/Research Assistant Department of Chemistry, Oakland University, Rochester, Michigan |
| 1981 |
Research Assistant, Oxymetals (Udylite) Warren, Michigan |
| 1996-1998 |
Adjunct Assistant Professor, Department of Chemistry University of North Carolina at Greensboro, Greensboro, NC |
| 1996 |
NIH (NCI) Grant Review, ad hoc Scientific Meetings and Conference (R13) Grant Program |
| 1999-Present |
Consultant, Syracuse Research Corporation, North Syracuse New York |
|
American Association for the Advancement of Science Radiation Research Society American Chemical Society Sigma Xi Society for Applied Spectroscopy |
| Awards | |
| 1993 |
Young Investigator Travel Award Miller Conference on Radiation Chemistry, Bowness-on-Windermere, Cumbria, England |
| 1991 |
Young Investigator Travel Award The 9th International Congress Research, Toronto, Ontario, Canada |
| 1988 |
Young Investigator Travel Award 36th Annual Meeting of the Radiation Research Society, Philadelphia, PA |
| Invited Lectureships | |
| April 21-26, 2001 |
Swarts, S.G., "Influence of Cu+2 and Fe+3 on Yields of End-Products in Irradiated Hydrated DNA." Presented at the 48th annual meeting of the Radiation Research Society in San Juan, Puerto Rico |
| September 24-29, 2000 |
Swarts, S.G., Falcone, J.M., "Prevention of the artefactual oxidation of DNA nucleobases during the trimethylsilylation of DNA hydrozylates." Presented at the 27th annual meeting of the Federation of Analytical Chemistry and Spectroscopy Societies in Nashville, TN |
| April 17-22, 1999 |
Swarts, S.G., Falcone, J.M., "Controlling the artifactual oxidation of DNA nucleobases that occurs during the trimethylsilylation of DNA hydrozylates." Presented at the International Workshop on Radiation Damage to DNA: Lesions, Mechanisms and Consequences at the University of North Carolina at Chapel Hill, Chapel Hill, NC |
| April 19-24, 1997 |
Swarts, S.G., Falcone, J.M., "Use of DNA with differing monovalent cations in the study of the effects of hydration and conformation on radiation-induced DNA damage." Presented at the International Workshop on Radiation Damage in DNA: Techniques, Quantitation and Mechanisms in Bownesson-Windermere, Cumbria, England |
| June 5, 1996 |
Swarts, SG, "End product formation in irradiated DNA: Hydration effects." Presented at the NIH(NCI) Division of Research Grants Radiation Study Section Workshop "The Radiation Chemistry of DNA", Chevy Chase, MD |
| May 2, 1996 |
Swarts, SG, "Radiation-induced end-products in hydrated DNA." Presented at the University of Rochester, Department of Biophysics, Rochester, NY |
| April 19, 1996 |
Swarts SG, "Formation of radiation-induced DNA damage in hydrated DNA." Presented at the University of North Carolina at Greensboro, Chemistry Department, Greensboro, NC |
| August 27 - September 1, 1995 |
Swarts SG, Becker D, Sevilla MD, Wheeler KT, "Importance of hole and electron transfer processes to end product formation in gamma-irradiated hydrated DNA." Presented at the 10th International Congress of Radiation Research in Würzburg, Germany |
| April 1-6, 1995 |
Swarts SG, Becker D, Sevilla MD, Miao L, Wheeler KT, "Formation of DNA damage induced by the radiolysis of the hydration layer". Presented at the 43rd Annual Meeting of the Radiation Research Society in San Jose, CA |
| October 1-6, 1994 |
Swarts SG, "Quantitation of DNA base damage by using gas chromatography/mass spectrometry". Presented at the International Workshop on Radiation Damage in DNA: Structure/Function Relationships at Early Times in Gleneden, OR |
| October 1-6, 1994 |
Swarts SG, Sevilla MD, Becker D, Wheeler KT, "Radiation-induced DNA damage as a function of DNA hydration". Presented at the International Workshop on Radiation Damage in DNA: Structure/Function Relationships at Early Times in Gleneden, OR |
| April 3-8, 1993 |
Swarts SG, Sevilla MD, Becker D, Smith G, Wheeler KT. "Radiation-induced damage in hydrated DNA models". Presented at the Miller Conference on Radiation Chemistry in Bownesson-Windermere, Cumbria, England |
| June 14-18, 1992 |
Swarts SG. Radiation-induced DNA damage as a function of hydration. Invited talk presented at the Conference on Pathways to Radiation Damage in DNA, Meadow Brook Hall, Oakland University, Rochester, MI |
| March 30, 1992 |
Swarts SG. The influence of the hydration layer on radiation-induced DNA damage. Invited talk presented at Roswell Park Cancer Institute, Biophysics Department, Buffalo, New York |
| July 7-12, 1991 |
Swarts SG. Is there relevance of in vitro DNA damage to in vivo DNA damage? Invited talk presented at the 9th International Congress of Radiation Research, Toronto, Ontario, Canada |
| May 30, 1990 |
Swarts SG. Radiation-induced DNA damage as a function of the degree of DNA hydration. University of Vermont, Burlington, VT |
| Current Interests | |
| 1. | Development of trace analysis assays for the detection of chemically distinct nucleotide, nucleoside, and base damage products formed from reactions of ionizing radiation and activated oxygen species with DNA and DNA model compounds using high performance liquid chromatography and gas chromatography/mass spectrometry techniques. |
| 2. | Control and regulation of removal of chemically distinct DNA lesions from mammalian cellular DNA. |
| 3. | Determine the reaction mechanisms involved in the formation of radiation-induced specific DNA base damage from their free radical precursors and the influence of environmental factors (i.e. hydration, radical scavengers, etc.) on these mechanisms. |
| 4. | Developing and implementing biomarkers (DNA base damage products, polyamines, acetylated histones, etc.) as diagnostic/prognostic indictors in radiation therapy protocols and in the assessment of individual susceptibility to cancer and age-related diseases. |
| 5. | Elucidate the mechanisms by which sulfur-based radicals are formed in the irradiation of thiols. |
| Past Interests | |
| 1. | Study of the reactions of radical cations formed from the one-electron oxidation of purine, pyrimidines, 5-halopyrimidines and 6-azapyrimidines. |
| 2. | Determining the relative reactivities of radiolytically produced radical anions formed from the addition of an electron to aldehydes, ketones and carboxylic acids. |
| 3. | Study of the free radicals produced from the direct radiolysis of diacyl phosphatidyl cholines and the fate of these radicals. |
| 4. | Characterization of ester cation radicals and elucidation of their reaction mechanisms. |
| 5. | Development of techniques for the detection of radiolytically produced covalent bonding between DNA and lipid membranes. |
| 6. | Study of the radiolysis of DNA using nitroxyl based spin probes. |
| 7. | Determining the reactions of the radiolytically produced thiyl radical under aerobic and anaerobic conditions. |
| March 1, 1999 - February 28, 2004 |
Radiation Damage to DNA: Effects of Modifiers and LET; Consultant and analytical support;
Michael D. Sevilla, PI NIH (NCI) R01-CA45424-12, $600,624 |
| April 1, 1998 - March 31, 2002 |
Radiation-Induced DNA Damage as a Function of Hydration; PI NIH (NCI) R01-CA58649-04, $286,675 |
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Books and Chapters Swarts SG, Miao L, Wheeler KT, Sevilla MD, Becker D. "Radiation-induced DNA damage as a function of DNA hydration". In: Radiation Damage in DNA: Structure/Function Relationships at Early Times ed. A.F. Fuciarelli and J.D. Zimbrick, Battelle Press, Columbus, OH, pp. 131-138, 1995. Swarts SG, "Importance of hole and electron transfer processes to end product formation in gamma-irradiated hydrated DNA." In: Radiation Research 1895 - 1995. ed. U. Hagen, H. Jung, C. Streffer, and D. Harder, Universitätsdruckerei H. Stürtz AG, Würzburg, Germany, pp. 208 - 211, 1996. Sevilla MD, LaVere T, Becker D, Wang W, Swarts SG, Wheeler KT. "Effects of DNA hydration on primary radical formation and reaction: which processes are of biological consequence?" In: Radiation Research 1895-1995. ed. U.Hagen, H.Jung, C.Streffer, and D.Harder, Universitätsdruckerei H. Stürtz AG, Würzburg, Germany, pp. 262 - 265, 1996. Journal Articles
Aydogan .B, Marshall D.T., Swarts S.G., Turner J.E., Boone A.J., Richards N.J., and Bolch W.E. 2001. Site-specific OH attack to the sugar moiety of DNA: A comparison of experimental data and computational simulation. Radiat. Res., 2002;Vol 157(1), 38-44.
Blackstock, A.W., Lightfoot, H., Case, L.D., Tepper, J.E., Mukherji, S.K., Mitchell, B.S., Swarts, S.G., and Hess, S.M. Tumor uptake and elimination of dFdCyd (Gemcitabine) afer deoxycytidine kinase gene transfer: Correlation with in vivo tumor response. Clin. Cancer Res., 2001; Vol 7(10), 3263-8
Pimblott, S.M., Osman, R., Swarts, S.G., Bernhard, W.A., Ward, J.F., and Doetsch, P.W. The Radiation Chemistry of DNA - A Radiation Study Section Workshop. Radiat. Res., 1997; Vol. 147, 511-525.
Razskazonskii, Y., Swarts, S.G., Falcone, J.M., Taylor, C., and Sevilla, M.D., Competitive electron scavenging by chemically modified pyrimidine bases in bromine-doped DNA: relative efficiencies and relevance to intrastrand electron migration distances. J. Phys. Chem., 1997; Vol. 101, 1460-1467.
Swarts, S.G., Becker, D., Sevilla, M., Wheeler, K.T. Radiation-induced DNA damage as a function of hydration. II. Base damage from electron-loss centers. Radiat. Res., 1996; Vol. 145, 304-314.
Swarts, S.G., Smith, G.S., Miao, L., Wheeler, K.T. Effects of formic acid hydrolysis on the quantitative analysis of radiation-induced DNA base damage products assayed by gas chromatography/mass spectrometry. Radiat. Environ. Biophys., 1996; Vol. 35, 41-53.
Swarts SG, Sevilla MD, Becker D, Tokar CJ, Wheeler KT, Radiation-induced DNA damage as a function of hydration. I. Release of unaltered bases. Radiat. Res., 1992; Vol. 129, 333-344.
Swarts SG, Nelson GB, Wallen CA, Wheeler KT, Radiation-induced cytotoxicity, DNA damage and DNA repair: Implications for cell survival theory. Radiat. Environ. Biophys., 1990; Vol. 29, 93-102.
Swarts SG, Becker D, Debolt S, Sevilla MD, Electron spin resonance investigation of the structure and formation of sulfinyl radicals: Reactions of the peroxy radical with thiols. J. Phys. Chem., 1989; Vol. 93, 155-161. Becker D, Swarts SG, Champagne M, Sevilla MD, An ESR investigation of the reactions of glutathione, cysteine and penicillamine thiyl radicals: Competitive formation of RSO., R., RSSR- and RSS.. Int. J. Radiat. Biol., 1988; Vol. 53, 767-786. Fish JR, Swarts SG, Sevilla MD, Malinski T, Electrochemistry and spectroelectro-chemistry of nitroxyl free radicals. J. Phys. Chem., 1988; Vol. 92, 3745-3751. Sevilla MD, Becker D, Swarts SG, Herrington J, Sulfinyl radical formation from the reaction of cysteine and glutathione thiyl radicals with molecular oxygen. Biochem. Biophys. Res. Comm., 1987; Vol 144, 1037-1042.
Swarts SG, Sevilla MD, Radiolysis of spin labeled DNA: An ESR investigation. Radiat. Res., 1987; Vol. 112, 21-35.
Rideout J, Symons MCR, Swarts SG, Sevilla MD, An ESR study of lactone radical cations formed in gamma irradiated freon matrices. J. Phys. Chem., 1985; Vol 89, 5251-5255. Sevilla MD, Becker D, Swarts SG, ESR investigation of intermolecular hydrogen transfer and alkyl radical attack in ester cation radicals. J. Phys. Chem., 1985; Vol. 89, 2638-2646. Sevilla MD, Becker D, Sevilla CL, Swarts SG, Reactions of the methyl and ethyl formate cation radicals: Deuterium isotope effects. J. Phys. Chem., 1985; Vol. 89, 633-636. Sevilla MD, Becker D, Sevilla CL, Swarts SG, An ESR investigation of ester cation radicals at low temperatures: Proton transfer and rearrangement reactions. Faraday Disc. Chem. Soc., 1984; Vol. 78, 71-81. Sevilla MD, Becker D, Sevilla CL, Swarts SG, ESR investigation of ester cation radicals in a freon matrix at low temperatures: Evidence for unusual barriers to methyl group rotation and intermolecular bonding. J. Phys. Chem., 1984; Vol. 88, 1701-1706. Sevilla MD, Swarts SG, Riederer H, Huttermann J, An ESR investigation of the 5-halouracil and 5-halocytosine pi cations produced by attack of the Cl2 radical. J. Phys. Chem., 1984; Vol. 88, 1601-1605. Sevilla CL, Swarts SG, Sevilla MD, An ESR study of radical intermediates formed by gamma-radiolysis of tripalmitin and dipalmitoyl phosphatidylethanolamine. J. Amer. Oil Chem. Soc., 1983; Vol. 60, 950-969. Sevilla MD, Sevilla CL, Swarts SG, Hydrogen abstraction reactions by amide electron adducts: A comparison to acid, ester, aldehyde and ketone electron adducts. Radiat. Phys. Chem., 1982; Vol. 20, 141-147. Sevilla MD, Swarts SG, Electron spin resonance study of radicals produced by one-electron loss from 6-azauracil, 6-azathymine and 6-azacytosine. Evidence for both sigma and pi radicals. J. Phys. Chem., 1982; Vol 86, 1751-1755. Sevilla MD, Morehouse KM, Swarts SG, An ESR study of electron reactions with esters and triglycerides. J. Phys. Chem., 1981; Vol. 85, 923-927. Sevilla MD, Swarts SG, Bearden R, Morehouse KM, Vartanian T, An ESR study of electron reactions with carboxylic acids, ketones and aldehydes in aqueous glasses. J. Phys. Chem., 1981; Vol. 85, 918-923.
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