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Mark E. Dumont, Ph.D.
G protein-coupled receptors mediate cellular responses to a variety of sensory stimuli, hormones, growth factors, and neurotransmitters. We are interested in understanding the molecular mechanism by which the extracellular signal is transduced to G proteins in the cytoplasm, via seven-transmembrane receptors. We are using yeast genetics to study the regulation of signaling and the functional and structural properties of fungal and mammalian receptor mutants.
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Thomas E. Gunter, Ph.D.
Calcium is a second messenger that activates many enzymes in the cell. We are interested in the physiological properties of calcuim ion transport in the mitochondria and the role of calcium in the regulation of ATP production. Manganese is a toxin believed to use similar ion channels as calcium. Because Manganese is an additive in gasoline fuel, we are investigating the organelles, ion transport properties, target proteins and toxicity of manganese.
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George A. Kimmich, Ph.D.
Excitatory transmitters, such as glutamate, become potent neurotoxins and can induce seizures if not efficiently recaptured by surrounding cells. Release and uptake of such neurotransmitters in the central nervous system is a process, carefully regulated by signal transduction events. Our research focuses on glutamate metabolism, the mechanism and regulation of glutamate uptake by astrocytic cells, and the pathway that returns glutamate metabolites to neurons to replenish the neuronal transmitter stores.
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Hartmut Land, Ph.D.
Carcinogenesis is caused by multiple cooperating genetic lesions, leading to a progressive deregulation of intra-cellular signaling and cell cycle control. Such mutations result in oncogene activation or loss of tumor-suppresser gene function. We are studying the mechanisms by which these mutant genes cooperate in malignant transformation. This transformation process involves the integration of multiple signals that regulate cell cycle-dependent kinase complexes, which can switch cells into a state of uncontrolled rapid cell proliferation--cancer.
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