My Contact Information

Emeritus Professor of Biochemistry and Biophysics
Ph.D. Cornell University 1937
M.D. University of Rochester 1945

The isolated rat liver, perfused for 12 or 24 hours, has been used as a closed metabolic system for evaluating the regulatory effects of hormones and metabolic inhibitors in the net biosynthesis of specific plasma proteins with emphasis on the acute phase proteins. Current studies are seeking to define the production of Interlukin-6 and its interactions with glucocorticoids in the isolated perfused liver system.

Recent Publications

Miller LL, Treat DE, Fridd B, Wemett D (1990) Effects of streptozotocin diabetes in the rat on blood levels of ten specific plasma proteins and on their net biosynthesis by the isolated perfused liver. Hepatology, 11:635-45

Sparks JD, Sparks CE, Miller LL (1989) Insulin effects on apolipoprotein B production by normal, diabetic and treated-diabetic rat liver and cultured rat hepatocytes. Biochem J., 261:83-8

Miller LL, Izzo MJ, Wemett D (1988) Persistent grossly elevated plasma immunoglobulin A levels in untreated streptozocin-induced diabetic rats. Diabetes, 37:177-84

Miller LL, Izzo MJ, Wemett D, Panner BJ, Schenk EA (1988) Increased plasma IgA, sIgA, and C3- and IgA-containing immune complexes with renal glomerular deposits in diabetic rats. Diabetes, 37:185-93

Miller LL (1983) Role of known hormones in regulating synthesis and secretion of plasma proteins by the isolated perfused rat liver. Plasma Protein Secretion by the Liver Edited by H. Glaumann, T. Peters Jr. and C. Redman. Academic Press Inc. (London) Limited,, 133-152

Contact Information

E-Mail: Leon_Miller@urmc.rochester.edu

Leon Miller
Department of Biochemistry and Biophysics
University of Rochester School of Medicine and Dentistry
601 Elmwood Ave, Box 712
Rochester, New York 14642

Office: Medical Center 5-6824
Telephone: (585) 275-3904; Fax: (585) 275-6007