Microarray Core Facility: This core facility provides a number of services which utilize the Affymetrix GeneChip System. GeneChip expression analysis arrays are available for human, murine, rat and yeast analysis. In addition, the facility supports the following directed arrays available from Affymerix: HIV PRT Plus, CYP450, p53 probe arrays, rat toxicology arrays, rat neurobiology arrays and human SNP mapping. The microarray core is also equipped with a variety of bioinformatics tools for data management and analysis. Contact: Andy Brooks, 275-6382.
Nucleic Acid Core: The Nucleic Acid Core provides four types of services: 1) DNA sequencing, 2) oligonucleotide synthesis, 3) genetic analysis, and 4) Perkin-Elmer nucleic acid reagents. Contact: Jack Maniloff, 275-3413.
MicroChemical Protein/Peptide Core Facility: This facility is an analytical service available to all members of the University community. The facility provides compositional and structural elucidation of proteins and peptides. Contact: Gurrinder Bedi, 275-8696.
Transgenic Core: At this time, this core provides expertise and assistance in the production of transgenic mouse models by either DNA microinjection or gene targeting in embryonic stem (ES) cells. Contact: Dr. C.A. Pinkert, 273-3438.
Electron Microscope Imaging Core: This core facility provides research support in electron microscopy using two microscopes: a Hitachi 7100 Electron Microscope and a Zeiss 902 microscope. In addition, a state-of-the-art scanning electron microscope will be acquired in the near future. Contact: Karen Jensen 275-1954.
Cell Sorting Core: The cell sorting core assists users to adapt and modify existing flow cytometric methods or to develop new procedures for their specific requirements. Contact: Peter Keng, 275-6332.
Real Time Confocal Core: This core comprises a Noran OZ real-time laser scanning confocal microscope and associated SGI computers for operating the instrument and for off-line data analysis. Contact: Trevor Shuttleworth, 275-2076.
Pathology/Morphology Imaging Facility: This core facility provides a Leica Confocal Microscope, an Olympus Flourescent Microscope, and an Arcturus PixCell Laser Capture Microscope for use by the SMD faculty. All users are provided the ability and expertise to characterize normal and abnormal biologic specimens, from the level of the intact mouse to subcellular structures. Director: Ray Baggs, 275-2655; Contact: David Pasternack, 273-4097, for an appointment to learn the equipment. Schedule sign-up on the web.
Vivarium: The Vivarium is a centralized resource facility with staff and programs that support the research and educational uses of laboratory animals. The Vivarium has the capability to house and care for in vivo studies using radioisotopes, infectious agents up to Class II, chemical carcinogens, and certain other hazardous substances. Contact: Jeffrey Wyatt, 275-2651.
Cold Storage Core (CSC): The CSC provides a discreet area where investigators can keep freezers for long term storage of research materials. The entire facility is alarmed and power protected. Contact Richard Reichman, 275-5871.
Biosafety Level 3 (BSL-3) Core: The Biosafety level three facility (BSL-3) is available for the use of any researcher at the university whose work requires manipulation of biological agentswhich may cause serious or potentially lethal disease as a result of exposure by the inhalation route. Contact Martin Pavelka 275-4670.
